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Mind and Microbes: Can Probiotics treat Anxiety and Depression?

August 12, 2019 By Dr. Halls

Any new break throughs for the treatment of anxiety and depression are VERY exciting for the medical world.

One of these recent break throughs in medicine is the connection between a healthy, functioning gut and our mental and emotional well being.

This post will look at the research surrounding the idea that probiotics and gut health may have a significant impact for the treatment of depression and anxiety.

Hector Hector
Did you know 100 trillion gut bacteria live in the intestinal tract?

Dr. Halls Dr. Halls
Yes, collectively the bacteria (good and bad) and other microorganisms that live in the gut are known as ‘gut microbiota’

Talking Moose
Talking Moose
Wow, the gut is like a giant, live, wiggly organ.


 
 

Depression and Anxiety Disorders

Depression and anxiety disorders are major issues for millions of people worldwide.

anxiety disorders

Indeed, according to the World Health Organization (WHO) depression affects the lives of over 300 million people worldwide.

Likewise, large population surveys1 show that up to 33.7% of the population suffer from one of the anxiety disorders at some point in their lifetime.  That is around a third of the total population.

Often, the symptoms of anxiety and depression overlap.  That is anxiety sufferers may experience depressive symptoms and depression is often accompanied by anxiety.

Tyler Tyler
Americans have the highest rate of mental health disorders according to The World Health Organization2.

Dr. Halls Dr. Halls
Interestingly, but not surprisingly, Americans also have one of the worst diets in the world.

Talking Moose
Talking Moose
Is there a link? Go figure guys!


 
 

The Mind-Body Connection

Western cultures tend to maintain a more distinct separation between the mind and body.

Well, Eastern cultures traditionally more fully embrace the idea of a mind-body connection. Indeed, physicians in the West treat illness or ‘dis’ease in the body3 rather than concentrating on maintaining a healthy balance between body and mind.

What exactly does a mind-body connection mean?  Well, it is a two way relationship between our thoughts, beliefs and emotions and the body’s biological function and vice-versa.

So, basically, a person’s mind has a direct effect on the health of the body.  Likewise, the health of the body, including diet and exercise, directly impacts the mind and emotions.

Talking Moose
Talking Moose
Okay, Doc.  We get it – there is a mind-body connection …  but where are we going with this?

Dr. Halls Dr. Halls
Well, just a little prelude before we get into the gut-brain axis.

Talking Moose
Talking Moose
I knew there was a mind-gut connection. My gut tells my brain regularly that it wants donuts … or does my brain tell my gut that it needs donuts … Hmmmmm … Confusing.


 
 

What exactly is the gut-brain Axis?

Talking Moose

Well, the gut-brain axis is woven into the very fabric of our language. Think about the following expressions:-

  • I just had a gut feeling that something wasn’t right
  • Butterflies in my belly
  • Trust your gut
  • I am gutted
  • My stomach was in my mouth
  • The story was gut wrenching

… and lastly even Napoleon knew that

“an army marches on it’s stomach“

So, even though the connection between the gut and emotions has been known on a subconscious level for decades, medical research is only just catching up.

Talking Moose
Talking Moose
Trust your gut, you say? Really? Have you met my gut?


 
 

The Biology of the Gut-Brain Axis

For many decades medical researchers thought that the microorganisms in the gut are mainly beneficial for keeping the ‘bad’ bacteria at manageable levels4.

probiotics for anxiety

It is well known that the gut flora also helps to digest and metabolise foods.

Furthermore, the gut microbiota plays an important role in the immune system too.

The composition of the gut microbiota also plays a part in the inflammatory response.

The very latest research is starting to show that an imbalance in gut microbiota may play a part in many chronic illnesses. 5,6,7

Talking Moose
Talking Moose
Who would have thought that our emotions and health are affected by a load of bacteria and microorganisms?

Hector Hector
Nearly 2,500 years ago Hippocrates claimed that, ‘all disease begins in the gut’ and modern research shows he was not that wrong.


 
 

What are Probiotics and Prebiotics?

Basically, probiotics are the ‘good’ live bacteria, yeast and microorganisms in your gut that are beneficial to well-being and health.

So, probiotics are found in abundance in certain foods, especially fermented foods.  Examples of foods rich in probiotics are:-

probiotics for anxiety
  • Live yoghurt
  • Sauerkraut
  • Kimchi
  • Miso
  • Kefir

Also, important to the whole gut health are the foods that feed the probiotics, and these are known as ‘prebiotics’ and include:-

probiotics for anxiety
  • garlic
  • bananas
  • onion
  • leeks
  • chives
  • avocado
  • peas
  • soybeans
Brittany Brittany
You can also buy probiotic supplements from a pharmacy or Health food Store. But that’s a whole other article.

Dr. Halls Dr. Halls
Yes, but naturally fermented food is way superior to probiotic supplements for gut health.


 
 

Probiotics for Anxiety

However, this post is all about the role of gut flora and anxiety symptoms, so let’s not digress.

The recent research shows that the gut microbiota is very important to both brain development and healthy brain function.

Indeed a recent 2016 research study8 shows that,
 

… diet and gut health affects symptoms of stress related disorders, depression, and anxiety through changes in the gut microbiota

 
Initial studies on some mental illnesses including :-

  • Anxiety
  • Depression
  • Schizophrenia
  • Autism spectrum disorder

found that subjects often presented with a marked gut dysfunction at the same time as the mental health disorder.

Furthermore, recent research suggests that improving the gut health with probiotics in turn improves the symptoms of depression, especially anxiety disorders9,10,11.

Hector Hector
Studies in both animals and humans show that probiotics can have an anxiolytic effect. 12,13,14

Jessica Jessica
What is an anxiolytic?

Hector Hector
It is any substance or treatment that reduces anxiety.


 
 

Research on Probiotics for Anxiety and Depression

There is a whole body of scientific research studies now on the effects of probiotics for help with anxiety and depression.

anxiety attacks

Interestingly, an imbalance in gut microbes may be linked with causing depression and anxiety.  However, emotional trauma or stress, in turn, causes an imbalance in the gut microbiota.  The brain-gut axis really is a two-way interactive mechanism.  This is known as a ‘bidirectional’ process.

One large 2017 meta-analysis examined probiotics for anxiety.  This recent study examimes ten  pieces of research on probiotics and anxiety.

The study concludes that probiotics do decrease anxiety symptoms, both in healthy individuals and those suffering with anxiety disorders. Furthermore, fermented foods and probiotics have had some impressive effects15 on the symptoms of social anxiety disorder (SAD).

However, the study stresses that in the future more rigourous trials are necessary  to determine :-

  • which specific probiotics are the most effective
  • what dosage of probiotics is optimal
  • the length of treatment with probiotics for maximal effectiveness

Conclusions

Whilst the above findings of probiotics for anxiety and depression are exciting we do need to exercise some caution.

Headlines, such as ‘Probiotics are the New Prozac‘ are misleading and possibly jumping the gun a little.

It has been well known for many years, that exercise and diet have a beneficial effect on symptoms of both depression and anxiety.

So, whilst probiotics may well help ease symptoms do not give up proper medical supervision and treatment with your physician.

If you suffer mild anxiety, that does not require medical treatment, then adding some fermented foods to your diet, or taking a probiotic supplement, may well help.

anxiety attack

However, if you’re anxiety or depression needs medical care, be sure to continue traditional treatments such as:-

  • Cognitive behavioral therapy
  • Medications: Selective serotonin reuptake inhibitors (SSRIs), Benzodiazepines and anti-depressants
  • Psychotherapy
  • Exercise
  • Relaxation Techniques: meditation, yoga, etc.

Always discuss supplemental treatments, such as probiotics, with your physician.  Any specialist should be up-to-date with all the latest research and able to advise you.

However, initial studies show VERY few to no side effects associated with taking probiotics.

An all-round healthy diet (including probiotics) and exercise plan will undoubtedly help with anxiety.

Talking Moose
Talking Moose
Just one question. What actually is Kefir?


 
 

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